Anti-amyloid precursor protein immunoglobulins inhibit amyloid-β production by steric hindrance
نویسندگان
چکیده
منابع مشابه
Inhibition of amyloid-β production by anti-amyloid precursor protein antibodies in primary mouse cortical neurones.
Current therapies for Alzheimer's disease only treat the symptoms of the disease. We have previously developed a novel monoclonal antibody, 2B3, which binds to the β-secretase cleavage site in amyloid precursor protein (APP) and reduces the production of amyloid-β (Aβ) in human cell lines. To determine whether the antibody was likely to be effective in mouse models of amyloid pathology in vivo,...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2010
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2010.07942.x